NIR-infrared Semiconducting Polymer Dots with Efficient Energy Transfer for Fluorescence and Photoacoustic Bimodal Imaging

Countdown
0 days

Important Dates

Conference:

Apr. 22-24, 2019

Full Paper Due: Mar. 18, 2019

Abstract Due: Mar. 18, 2019

Audience Registration Due:
Apr. 22, 2019

Presentations of The Spring World Congress on Engineering and Technology (SCET 2017)

● NIR-infrared Semiconducting Polymer Dots with Efficient Energy Transfer for Fluorescence and Photoacoustic Bimodal Imaging
Author(s)
Shichao WANG
Affiliation(s)
University of Macau
KEYWORDS
NIR-infrared Semiconducting Polymer Dots, Efficient Energy Transfer, Fluorescence, Photoacoustic Bimodal Imaging
ABSTRACT
A series of -conjugated semiconducting polymers nanoparticles (Pdots) 1~6. 1~4 exhibited near-infrared fluorescence, ultrahigh brightness and large Stokes shifts. Both 5,6 have strong absorption because of the introduction of BODIPY derivatives which have high extinction coefficients. Under excitation by 532 nm laser, 4 has the strongest PA emission but endowed with very low fluorescence quantum yield (=0.09). Two-component Pdots (polymers 1 and 5, or 1 and 6) were prepared by an ultrasonication-assisted co-precipitation method and demonstrated effective fluorescence resonance energy transfer (FRET) process and substantially PA quenching. Greater fluorescence quenching was found in 1,6 Pdots due to more BODIPY derivatives proportion in 6 conjugated backbone, which also lead to PA quenching. In addition, Pdots15 was used in cell imaging because of the better FRET and longer fluorescence emission, the result shown that Pdots15 could labelled specific cellular and subcellular effectively. 1~4 were also demonstrated deserved photoacoustic imaging effect in zebrafish model. Acknowledgement: This work was supported by the Macao Science and Technology Development Fund under Grant No.: 052/2015/A2, the Multi-Year Research Grant of University of Macau under grant No.: MYRG2016-00058-FHS, and Faculty allocated start-up grant.