A Boronate-containing Fluorescent Probe with Rapid Response to Peroxynitrite

Countdown
0 days

Important Dates

Conference:

Apr. 22-24, 2019

Full Paper Due: Mar. 18, 2019

Abstract Due: Mar. 18, 2019

Audience Registration Due:
Apr. 22, 2019

Presentations of The Spring World Congress on Engineering and Technology (SCET 2017)

● A Boronate-containing Fluorescent Probe with Rapid Response to Peroxynitrite
Author(s)
Jingyun Tan
Affiliation(s)
University of Macau
KEYWORDS
A Boronate-containing Fluorescent Probe with Rapid Response to Peroxynitrite
ABSTRACT
Peroxynitrite (ONOO-) is one of highly reactive nitrogen species involved in various biological processes. Due to its short life-time in physiological condition, the simultaneous detection of ONOO- is difficult. Therefore, there’s an urgent need for probe which has rapid response to ONOO-. In this work, a boronate-containing phenothiazine derivative (DBoP) were designed. DBoP showed satisfying specificity and sensitivity towards ONOO-, with a 150-folds enhancement in fluorescence intensity in less than one minute. This probe has great potential for real-time detection of ONOO-.